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It is necessary for normal endochondral ossification, the process by which the growing skeleton is formed. Mice lacking this gene often exhibit dwarfism and craniofacial abnormalities due to impaired chondrocyte proliferation.

In many malignancies—including breast, lung, prostate, and gastrointestinal cancers—miR-140 is significantly downregulated. It typically acts as a tumor suppressor by inhibiting cell proliferation, invasion, and metastasis while encouraging cell death (apoptosis).

Do you need focus on its impact or its oncology/cancer impact?

In oncology, miR-140 is widely investigated as both a biomarker and a therapeutic target due to its heavy involvement in cell carcinogenesis.

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