Abnormal Serum Light — Chain Ratio

While an abnormal ratio can sometimes indicate a serious condition, it is often caused by non-cancerous factors. Common Causes of an Abnormal Ratio

Conditions like multiple myeloma or MGUS (Monoclonal Gammopathy of Undetermined Significance) can cause one type of light chain to be overproduced, skewing the ratio. Abnormal Serum Light Chain Ratio

Because the kidneys filter these proteins out of your blood, chronic kidney disease can lead to higher levels and slightly altered ratios. While an abnormal ratio can sometimes indicate a

An indicates that the balance between two types of proteins— kappa and lambda free light chains—is outside the standard range of roughly 0.26 to 1.65 . These proteins are produced by plasma cells to help your immune system fight infections. Abnormal Serum Light Chain Ratio