Episode 22: Resignation May 2026

You can currently stream House on platforms such as Hulu, Amazon Prime Video, and Peacock. House: Season 3, Episode 22 - Rotten Tomatoes

: House suspects Dr. Wilson is depressed and sluggish. In a classic "House" move, he spikes Wilson’s coffee with amphetamines (speed) to "help" him, leading to Wilson being hyperactive and jittery throughout the episode. Cast and Credits Director : Martha Mitchell. Writer : Pamela Davis. Guest Star : Piper Perabo plays the patient, Honey. Where to Watch Episode 22: Resignation

: A 19-year-old college student and karate practitioner suddenly coughs up blood during a workout. After numerous tests fail to explain her declining health, it is revealed she attempted suicide by ingesting a specific cleaner, which caused a bacterial infection. You can currently stream House on platforms such

: The episode’s primary B-plot centers on Dr. Eric Foreman’s decision to resign from House's team. He fears that he is becoming too much like House—cold, cynical, and willing to cross ethical lines. In a classic "House" move, he spikes Wilson’s