Greys Anatomy - Season 12 Instant

: Meredith Grey adjusts to life as a widow, moving back into her mother's house with her "sisters," Maggie Pierce and Amelia Shepherd. A major mid-season arc involves Meredith being brutally attacked by a patient, leading to a long recovery and therapy.

'Grey's Anatomy' Season 12 Trailer: "Everything Has Changed" Greys Anatomy - Season 12

: A bitter custody battle over their daughter, Sofia, ensues when Callie plans to move to New York with Penny. : Meredith Grey adjusts to life as a

: The couple's marriage collapses, leading to a divorce. However, they discover April is pregnant shortly before signing the papers. : The couple's marriage collapses, leading to a divorce

: Jason George (Ben Warren) was promoted to a series regular. Giacomo Gianniotti (Andrew DeLuca) also became a regular mid-season.

Season 12 of Grey's Anatomy , which premiered on September 24, 2015, is often described as the "season of rebirth". Following the death of Derek Shepherd in Season 11, the show shifted to a noticeably lighter, more "rom-com" tone, reminiscent of its earliest seasons.