Quabain Info

(pronounced WAH-bane ), also known as g-strophanthin , is a potent cardiac glycoside and steroid hormone naturally found in both African plants and mammals. Historically used by African hunters as an arrow poison due to its rapid effect on the heart, it is now primarily used as a research tool for studying cell signaling and, in some countries, as a medication for heart conditions. How it Works: The Na+/K+-ATPase Pump

: Conversely, abnormally high levels of endogenous ouabain are linked to chronic high blood pressure and heart failure. QUABAIN

: Produced in the adrenal glands and hypothalamus, it circulates in the blood at very low levels. Levels naturally rise during physical exercise or times of high salt intake. Modern Research & Potential Uses (pronounced WAH-bane ), also known as g-strophanthin ,

: It binds to and stops the pump, causing sodium to build up inside the cell. : Produced in the adrenal glands and hypothalamus,

Because of its role in cellular communication, researchers at institutions like ScienceDirect and Frontiers are exploring its potential beyond heart health:

: Experimental work has looked at ouabain's potential to "switch off" pain signals in peripheral neurons.

: This sodium buildup forces the cell to retain more calcium. In heart muscle cells, this extra calcium strengthens contractions.