While the film's ending leaves room for further exploration, director Vincenzo Natali has not produced a sequel, prioritizing individual storytelling over building a franchise. Splice (2009) - IMDb

: The scientists work for Newstead Pharmaceutics, originally researching DNA splicing to find medical benefits for humanity.

: Despite being forbidden from using human DNA, Elsa and Clive secretly proceed, giving birth to a life form with human characteristics and a "gene-spliced heart".

: As Dren grows at an accelerated rate, she develops complex emotional and physical traits that the scientists struggle to control, leading to a dark and "inventive" home stretch. Cast and Availability