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Lack of functional otoferlin or its C2 domain interaction prevents proper vesicle docking, leading to profound deafness. Summary Table: Otoferlin C2 Interactions Function/Location C2B-C2G Main interface for membrane binding C2D Crucial Ca 2+raised to the 2 plus power binding site; mutations affect sound encoding C2F-C2G Rearrange upon membrane binding to close structure Target Membrane Membrane where vesicles are docked

It tethers vesicles to the plasma membrane, facilitating sound encoding. tm,cc,jp

The study highlights that membrane binding involves a cooperative effort of multiple domains. Lack of functional otoferlin or its C2 domain

Based on the 2025 research regarding the protein , which is crucial for hearing and synaptic transmission, Based on the 2025 research regarding the protein

This guide focuses on the molecular mechanism of otoferlin-mediated vesicle docking and Ca 2+raised to the 2 plus power sensing in inner hair cells (IHCs). Role: Otoferlin acts as a key Ca 2+raised to the 2 plus power sensor for synaptic vesicle fusion in auditory IHCs.